Ultrastructural Analysis of Haemopoiesis in W/Wv Anaemic Mice

Matityahu Shaklai, Mehdi Tavassoli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Summary. This study is an ultrastructural analysis of haemopoiesis in W/Wv anaemic mice in whom the anaemia is caused by a defect in the haemopoietic stem cell. Cellularity of marrow is normal but there is an increase in the proportion of less mature cells suggesting a delay in maturation. In addition, heterochromatin constitutes a higher proportion than normal of the nucleus in most stages of maturation suggesting a defect in DNA activation. The findings suggest that in this strain not only the differentiation of the haemopoietic stem cell but also the maturation of the committed cell is defective.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalBritish Journal of Haematology
Volume40
Issue number3
DOIs
StatePublished - Nov 1978
Externally publishedYes

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