Ultrastructural alterations of normal blood cells and leukemic lymphoblasts incubated with vindesine

M. Djaldetti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of one of the vinca alcaloids derivatives, vindesine (YDS), on the ultrastructure of normal peripheral blood cells and leukemic lymphoblasts was examined in vitro. The drug caused an increase in the size of polymorphonuclear specific granules, but exerted no effect on the internal ultrastructure of control lymphocytes platelets, or leukemic lymphoblasts. However, the surface ultrastructure of all cell types examined showed alterations which were dose-dependent. The question whether the lack of internal impairment in the presence of membral alterations may be due to the relatively short exposure time to the drug is discussed.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalBiomedicine and Pharmacotherapy
Volume45
Issue number8
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • vindesine / normal blood cell / leukemic lymphoblast / cell ultrastructure
  • vindésine / cellule sanguine normale / lymphoblaste leucémique / ultrastructure des cellules

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