Ultrasonographic Features of Salivary Glands after Radioiodine Therapy in Patients with Thyroid Cancer

Nir Tsur*, Gal Avishai, Uri Alkan, Roy Hod, Thomas Shpitzer, Eden Bitton, Hanna Gilat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Chronic sialadenitis is the most common complication of radioactive iodine (RAI) treatment. The aim of the study was to ascertain sonographic features of the major salivary glands in patients with papillary thyroid cancer (PTC) treated with RAI. Methods: The database of a tertiary medical center was retrospectively searched for consecutive patients who underwent total thyroidectomy for PTC in 2011–2020 with ultrasound follow-up after 1 year. Changes in ultrasound features of the major salivary glands were compared between patients treated or not treated with RAI postoperatively. Results: The cohort included 158 patients, of whom 109 (69%) were treated postoperatively with RAI (mean dose, 131 mCi) and 49 were not (control group). Sonographic changes were observed in the major salivary glands in 43% of the study group and 18% of the control group (p = 0.002), including coarse echotexture, decreased echogenicity, fibrosis, and atrophy. Higher RAI doses were significantly correlated with the prevalence and severity of glandular changes (p < 0.0001). Conclusion: RAI treatment following thyroidectomy is associated with a dose–response effect and adverse changes in the major salivary glands and should be prescribed carefully. Level of Evidence: 4 Laryngoscope, 133:1271–1275, 2023.

Original languageEnglish
Pages (from-to)1271-1275
Number of pages5
JournalLaryngoscope
Volume133
Issue number5
DOIs
StatePublished - May 2023

Keywords

  • radioactive iodine
  • salivary glands
  • ultrasound

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