Ultrapure filter does not confer short-term benefits over two reverse osmosis systems in chronic hemodialysis patients

Ayelet Grupper; Moshe Shashar; Talia Weinstein; Orit Kliuk Ben Bassat; Shoni Levy; Idit F. Schwartz; Avital Angel; Aharon Baruch; Avishay Grupper; Gil Chernin; Doron Schwartz

Ultrapure filter does not confer short-term benefits over two reverse osmosis systems in chronic hemodialysis patients

Ayelet Grupper^*, Moshe Shashar, Talia Weinstein, Orit Kliuk Ben Bassat, Shoni Levy, Idit F. Schwartz, Avital Angel, Aharon Baruch, Avishay Grupper, Gil Chernin, Doron Schwartz

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Dialysate purity contributes to the inflammatory response that afflicts hemodialysis patients. Objectives: To compare the clinical and laboratory effects of using ultrapure water produced by a water treatment system including two reverse osmosis (RO) units in series, with a system that also includes an ultrapure filter (UPF). Methods: We performed a retrospective study in 193 hemodialysis patients during two periods: period A (no UPF, 6 months) and period B (same patients, with addition of UPF, 18 months), and a historical cohort of patients treated in the same dialysis unit 2 years earlier, which served as a control group. Results: Mean C-reactive protein, serum albumin and systolic blood pressure worsened in period B compared to period A and in the controls. Conclusions: A double RO system to produce ultrapure water is not inferior to the use of ultrapure filters.

Original language	English
Pages (from-to)	5-9
Number of pages	5
Journal	Israel Medical Association Journal
Volume	21
Issue number	1
State	Published - Jan 2019

Keywords

Hemodialysis
Reverse osmosis (RO)
Ultrapure filters (UPF)
Ultrapure water, water treatment system

Cite this

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title = "Ultrapure filter does not confer short-term benefits over two reverse osmosis systems in chronic hemodialysis patients",

abstract = "Background: Dialysate purity contributes to the inflammatory response that afflicts hemodialysis patients. Objectives: To compare the clinical and laboratory effects of using ultrapure water produced by a water treatment system including two reverse osmosis (RO) units in series, with a system that also includes an ultrapure filter (UPF). Methods: We performed a retrospective study in 193 hemodialysis patients during two periods: period A (no UPF, 6 months) and period B (same patients, with addition of UPF, 18 months), and a historical cohort of patients treated in the same dialysis unit 2 years earlier, which served as a control group. Results: Mean C-reactive protein, serum albumin and systolic blood pressure worsened in period B compared to period A and in the controls. Conclusions: A double RO system to produce ultrapure water is not inferior to the use of ultrapure filters.",

keywords = "Hemodialysis, Reverse osmosis (RO), Ultrapure filters (UPF), Ultrapure water, water treatment system",

author = "Ayelet Grupper and Moshe Shashar and Talia Weinstein and Bassat, {Orit Kliuk Ben} and Shoni Levy and Schwartz, {Idit F.} and Avital Angel and Aharon Baruch and Avishay Grupper and Gil Chernin and Doron Schwartz",

year = "2019",

month = jan,

language = "אנגלית",

volume = "21",

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journal = "Israel Medical Association Journal",

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T1 - Ultrapure filter does not confer short-term benefits over two reverse osmosis systems in chronic hemodialysis patients

AU - Grupper, Ayelet

AU - Shashar, Moshe

AU - Weinstein, Talia

AU - Bassat, Orit Kliuk Ben

AU - Levy, Shoni

AU - Schwartz, Idit F.

AU - Angel, Avital

AU - Baruch, Aharon

AU - Grupper, Avishay

AU - Chernin, Gil

AU - Schwartz, Doron

PY - 2019/1

Y1 - 2019/1

N2 - Background: Dialysate purity contributes to the inflammatory response that afflicts hemodialysis patients. Objectives: To compare the clinical and laboratory effects of using ultrapure water produced by a water treatment system including two reverse osmosis (RO) units in series, with a system that also includes an ultrapure filter (UPF). Methods: We performed a retrospective study in 193 hemodialysis patients during two periods: period A (no UPF, 6 months) and period B (same patients, with addition of UPF, 18 months), and a historical cohort of patients treated in the same dialysis unit 2 years earlier, which served as a control group. Results: Mean C-reactive protein, serum albumin and systolic blood pressure worsened in period B compared to period A and in the controls. Conclusions: A double RO system to produce ultrapure water is not inferior to the use of ultrapure filters.

AB - Background: Dialysate purity contributes to the inflammatory response that afflicts hemodialysis patients. Objectives: To compare the clinical and laboratory effects of using ultrapure water produced by a water treatment system including two reverse osmosis (RO) units in series, with a system that also includes an ultrapure filter (UPF). Methods: We performed a retrospective study in 193 hemodialysis patients during two periods: period A (no UPF, 6 months) and period B (same patients, with addition of UPF, 18 months), and a historical cohort of patients treated in the same dialysis unit 2 years earlier, which served as a control group. Results: Mean C-reactive protein, serum albumin and systolic blood pressure worsened in period B compared to period A and in the controls. Conclusions: A double RO system to produce ultrapure water is not inferior to the use of ultrapure filters.

KW - Hemodialysis

KW - Reverse osmosis (RO)

KW - Ultrapure filters (UPF)

KW - Ultrapure water, water treatment system

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Ultrapure filter does not confer short-term benefits over two reverse osmosis systems in chronic hemodialysis patients

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