Ultradian sleep-cycle variation of serotonin in the human lateral ventricle

J. M. Zeitzer, N. T. Maidment, E. J. Behnke, L. C. Ackerson, I. Fried, J. Engel, C. L. Wilson

Research output: Contribution to journalArticlepeer-review


Serotonin is thought to be intimately involved in the regulation of sleep and waking in humans, though the evidence for such is indirect. Using in vivo microdialysis, the authors show that serotonin in human ventricular CSF covaries with the state of consciousness. They hypothesize that CSF serotonin may be acting in an endocrine-like manner through activation of known leptomeningeal serotonin receptors and possibly participating in modulation of choroidal production of CSF.

Original languageEnglish
Pages (from-to)1272-1274
Number of pages3
Issue number8
StatePublished - 22 Oct 2002
Externally publishedYes


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