TY - JOUR
T1 - Type-specific streptococcal antibodies in pyodermal nephritis
AU - Bergner-Rabinowitz, Sonia
AU - Ofek, Itzhak
AU - Davies, Michael A.
AU - Rabinowitz, Kurt
N1 - Funding Information:
Received for publication March 26, 1971, and in revised form June 30, 1971. This work was supported by research grants no. CDIS-27 and no. 16 from the Heart Disease Control Program, U.S. Public Health Service. The authors thank Dr. Issac Ginsburg for his valuable criticism, and acknowledge the technical assistance of Lilian Zindel and Shaul Fleiderman in carrying out the type-specific antibody test. Please address requests for reprints to Dr. Sonia Bergner-Rabinowitz, Streptococcal Reference Laboratory, Government Central Laboratories, P. O. Box 6115, Jerusalem, Israel.
PY - 1971/11
Y1 - 1971/11
N2 - Type-specific antibodies in 656 samples of sera from 94 patients with glomerulonephritis associated with Group A streptococci provisional M-type 55, which was new to Israel, were studied. The antibodies were assayed by a micro-opsonophago- cytic method, using an in-vitro system of phagocytosis with peritoneal leukocytes from mice. All the sera were tested against provisional type 55. A sample of 270 sera collected from 40 patients was examined also against provisional type 60 and types 12, 25, and 49. Antibodies against provisional types 55 and 60 were found in a significant percentage of patients as compared with controls. In most cases, antibodies were detected two to four months after the initial disease and waned gradually over a period of five to seven months. The practical and potential usefulness of the test for type-specific antibody in nephritic patients is discussed.
AB - Type-specific antibodies in 656 samples of sera from 94 patients with glomerulonephritis associated with Group A streptococci provisional M-type 55, which was new to Israel, were studied. The antibodies were assayed by a micro-opsonophago- cytic method, using an in-vitro system of phagocytosis with peritoneal leukocytes from mice. All the sera were tested against provisional type 55. A sample of 270 sera collected from 40 patients was examined also against provisional type 60 and types 12, 25, and 49. Antibodies against provisional types 55 and 60 were found in a significant percentage of patients as compared with controls. In most cases, antibodies were detected two to four months after the initial disease and waned gradually over a period of five to seven months. The practical and potential usefulness of the test for type-specific antibody in nephritic patients is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0015155197&partnerID=8YFLogxK
U2 - 10.1093/infdis/124.5.488
DO - 10.1093/infdis/124.5.488
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0015155197
SN - 0022-1899
VL - 124
SP - 488
EP - 493
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -