Type 2 Diabetes in Pregnancy

Anil Kapur; Harold David McIntyre; Moshe Hod

doi:10.1016/j.ecl.2019.05.009

Type 2 Diabetes in Pregnancy

Anil Kapur^*, Harold David McIntyre, Moshe Hod

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Hyperglycemia is common during pregnancy, involving multisystem adaptations. Pregnancy-induced metabolic changes increase insulin resistance. Pregnancy-induced insulin resistance adds to preexisting insulin resistance. Preexisting pancreatic β-cell defect compromises the ability to enhance insulin secretion, leading to hyperglycemia. Women with type 2 DM have similar rates of major congenital malformations, stillbirth, and neonatal mortality, but an even higher risk of perinatal mortality. In utero type 2 DM exposure confers greater risk and reduces time to development of type 2 DM in offspring. Preconception care to improve metabolic control in women with type 2 diabetes is critical.

Original language	English
Pages (from-to)	511-531
Number of pages	21
Journal	Endocrinology and Metabolism Clinics of North America
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/j.ecl.2019.05.009
State	Published - Sep 2019

Keywords

Management
Pregnancy hyperglycemia
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ecl.2019.05.009

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title = "Type 2 Diabetes in Pregnancy",

abstract = "Hyperglycemia is common during pregnancy, involving multisystem adaptations. Pregnancy-induced metabolic changes increase insulin resistance. Pregnancy-induced insulin resistance adds to preexisting insulin resistance. Preexisting pancreatic β-cell defect compromises the ability to enhance insulin secretion, leading to hyperglycemia. Women with type 2 DM have similar rates of major congenital malformations, stillbirth, and neonatal mortality, but an even higher risk of perinatal mortality. In utero type 2 DM exposure confers greater risk and reduces time to development of type 2 DM in offspring. Preconception care to improve metabolic control in women with type 2 diabetes is critical.",

keywords = "Management, Pregnancy hyperglycemia, Type 2 diabetes",

author = "Anil Kapur and McIntyre, {Harold David} and Moshe Hod",

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AU - McIntyre, Harold David

AU - Hod, Moshe

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AB - Hyperglycemia is common during pregnancy, involving multisystem adaptations. Pregnancy-induced metabolic changes increase insulin resistance. Pregnancy-induced insulin resistance adds to preexisting insulin resistance. Preexisting pancreatic β-cell defect compromises the ability to enhance insulin secretion, leading to hyperglycemia. Women with type 2 DM have similar rates of major congenital malformations, stillbirth, and neonatal mortality, but an even higher risk of perinatal mortality. In utero type 2 DM exposure confers greater risk and reduces time to development of type 2 DM in offspring. Preconception care to improve metabolic control in women with type 2 diabetes is critical.

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KW - Type 2 diabetes

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Type 2 Diabetes in Pregnancy

Abstract

Keywords

UN SDGs

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