Two-stage plans for patient accrual in phase II cancer clinical trials

Y. J. Lee, M. Staquet, R. Simon, R. Catane, F. Muggia

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


This paper considers two-stage patient-accrual plans for phase II trials of anticancer drugs. The purpose is to identify the therapeutic level of drugs as either above or below a reference response rate. Using such a plan, decisions concerning the future disposition of drugs can be made more formally and objectively. The tables used to implement the plan are prepared for a 20% reference response rate, due to its wide acceptance in the design of phase II clinical trials.

Original languageEnglish
Pages (from-to)1721-1726
Number of pages6
JournalCancer Treatment Reports
Issue number11-12
StatePublished - 1979


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