Two-stage plans for patient accrual in phase II cancer clinical trials

Y. J. Lee; M. Staquet; R. Simon; R. Catane; F. Muggia

Two-stage plans for patient accrual in phase II cancer clinical trials

Y. J. Lee, M. Staquet, R. Simon, R. Catane, F. Muggia

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

This paper considers two-stage patient-accrual plans for phase II trials of anticancer drugs. The purpose is to identify the therapeutic level of drugs as either above or below a reference response rate. Using such a plan, decisions concerning the future disposition of drugs can be made more formally and objectively. The tables used to implement the plan are prepared for a 20% reference response rate, due to its wide acceptance in the design of phase II clinical trials.

Original language	English
Pages (from-to)	1721-1726
Number of pages	6
Journal	Cancer Treatment Reports
Volume	63
Issue number	11-12
State	Published - 1979

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abstract = "This paper considers two-stage patient-accrual plans for phase II trials of anticancer drugs. The purpose is to identify the therapeutic level of drugs as either above or below a reference response rate. Using such a plan, decisions concerning the future disposition of drugs can be made more formally and objectively. The tables used to implement the plan are prepared for a 20% reference response rate, due to its wide acceptance in the design of phase II clinical trials.",

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Two-stage plans for patient accrual in phase II cancer clinical trials

Abstract

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