Two Roads Diverge in the Sick Liver, Monocytes Travel Both

Ehud Zigmond, Chen Varol*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

Liver macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). In this issue of Immunity, Tran et al. and Remmerie et al. reveal that Ly6Chi monocytes in NASH replace dying resident Kupffer cells, while concomitantly are differentiating into distinct lipid associated macrophages.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalImmunity
Volume53
Issue number3
DOIs
StatePublished - 15 Sep 2020

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