Two novel biological active modified peptides from the cyanobacterium Microcystis sp.

A. Raveh, S. Carmeli

Research output: Contribution to journalArticlepeer-review

Abstract

Two novel biologically active short peptides, aeruginosins KY642, KY608 and the known aeruginosin 98A were isolated from the cyanobacterium Microcystis sp. strain (IL-323), which was collected from a water reservoir near Kfar-Yehoshua, Valley of Armageddon, Israel. Aeruginosins KY642, KY608 and 98A are linear modified peptides containing four building blocks, one of which is the modified amino acid, Choi (2-carboxy-6-hydroxyoctahydroindole). Aeruginosin KY642 and aeruginosin KY608 inhibit the activity of the photolytic enzyme trypsin with IC50 of 1.4 and 1.7 μg/mL, respectively.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalPhytochemistry Letters
Volume2
Issue number1
DOIs
StatePublished - 19 Feb 2009

Keywords

  • Aeruginosins
  • Cyanobacteria
  • Microcystis sp.

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