TY - JOUR
T1 - Two new antibiotics from the red sea sponge Psammaplysilla purpurea. Total 13C-NMR line assignment of psammaplysins A and B and aerothionin
AU - Rotem, M.
AU - Carmely, S.
AU - Kashman, Y.
AU - Loya, Y.
N1 - Funding Information:
Acknowledgement-We wish to thank Prof. J. Vacelct for the identification of the sponge. This research was supported by the United States-Israel Binational Science Foundation Grant 2201/80.
PY - 1983
Y1 - 1983
N2 - Two new tetra bromo metabolites (3 and 4), possessing the hitherto unknown spirocyclohexadienyloxazoline moiety, have been isolated from the sponge Psammaplysilla purpurea. The structure of compounds 3 and 4 have been elucidated by using spectroscopic methods and chemical degradations. A mechanism for the unusual base degradation is discussed. The PND, GATED, off resonance and SFORD spectra of 3, several degradation products, and aerotheonin (1) resulted in a total 13C-NMR line assignment. A possible biogenesis of the psammaplysins starting with dibromotyrosine is suggested.
AB - Two new tetra bromo metabolites (3 and 4), possessing the hitherto unknown spirocyclohexadienyloxazoline moiety, have been isolated from the sponge Psammaplysilla purpurea. The structure of compounds 3 and 4 have been elucidated by using spectroscopic methods and chemical degradations. A mechanism for the unusual base degradation is discussed. The PND, GATED, off resonance and SFORD spectra of 3, several degradation products, and aerotheonin (1) resulted in a total 13C-NMR line assignment. A possible biogenesis of the psammaplysins starting with dibromotyrosine is suggested.
UR - http://www.scopus.com/inward/record.url?scp=0020532337&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(01)91843-5
DO - 10.1016/S0040-4020(01)91843-5
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AN - SCOPUS:0020532337
SN - 0040-4020
VL - 39
SP - 667
EP - 676
JO - Tetrahedron
JF - Tetrahedron
IS - 4
ER -