TVP1022 attenuates cardiac remodeling and kidney dysfunction in experimental volume overload-induced congestive heart failure

Zaid A. Abassi, Yaron D. Barac, Sawa Kostin, Ariel Roguin, Elena Ovcharenko, Hoda Awad, Ayelet Blank, Orit Bar-Am, Tamar Amit, Jutta Schaper, Moussa Youdim, Ofer Binah*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background-Despite the availability of many pharmacological and mechanical therapies, the mortality rate among patients with congestive heart failure (CHF) remains high. We tested the hypothesis that TVP1022 (the S-isomer of rasagiline; Azilect), a neuroprotective and cytoprotective molecule, is also cardioprotective in the settings of experimental CHF in rats. Methods and Results-In rats with volume overload-induced CHF, we investigated the therapeutic efficacy of TVP1022 (7.5 mg/kg) on cardiac function, structure, biomarkers, and kidney function. Treatment with TVP1022 for 7 days before CHF induction prevented the increase in left ventricular end-diastolic area and end-systolic area, and the decrease in fractional shortening measured 14 days after CHF induction. Additionally, TVP1022 pretreatment attenuated CHF-induced cardiomyocyte hypertrophy, fibrosis, plasma and ventricular B-type natriuretic peptide levels, and reactive oxygen species expression. Further, in CHF rats, TVP1022 decreased cytochrome c and caspase 3 expression, thereby contributing to the cardioprotective efficacy of the drug. TVP1022 also enhanced the urinary Na+ excretion and improved the glomerular filtration rate. Similar cardioprotective effects were obtained when TVP1022 was given to rats after CHF induction. Conclusions-TVP1022 attenuated the adverse functional, structural, and molecular alterations in CHF, rendering this drug a promising candidate for improving cardiac and renal function in this disease state. (Circ Heart Fail. 2011;4:463-473.).

Original languageEnglish
Pages (from-to)463-473
Number of pages11
JournalCirculation: Heart Failure
Issue number4
StatePublished - Jul 2011
Externally publishedYes


  • CHF
  • Fibrosis
  • Heart
  • Kidney
  • TVP1022


Dive into the research topics of 'TVP1022 attenuates cardiac remodeling and kidney dysfunction in experimental volume overload-induced congestive heart failure'. Together they form a unique fingerprint.

Cite this