Turbulent and direct numerical simulations for optimizing mechanical heart valve designs

Michalis Xenos, Yared Alemu, Shmuel Einav, Danny Bluestein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Patients who receive mechanical heart valve (MHV) implants require mandatory anticoagulation medication after MHV implantation due to the thrombogenic potential of the devise. Optimization of MHV designs may facilitate in reducing the flow induced thrombogenic potential. To accomplish this goal highly resolved 3D geometries of different bileaflet mechanical heart valves were examined to study the contribution of distinct flow phases to platelet damage. Both turbulent and direct numerical simulations (DNS) were conducted and compared. A multiphase approach was formulated, in which the blood interacts with a large number of particles injected in the fluid domain, representing the platelets passing through the MHV. Loading histories experienced by the platelets were calculated by computing the combined effect of stress and exposure time. Platelet stress accumulation during randomized repetitive passages past the valves were calculated using a damage accumulation model. The results from the simulations were used as an input to our hemodynamic shearing device (HSD) which emulated the numerical loading waveforms, and platelet activity measured in order to quantify the thrombogenic potential of different MHVs.

Original languageEnglish
Title of host publicationProceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
Pages65-66
Number of pages2
EditionPART A
DOIs
StatePublished - 2009
Externally publishedYes
Event11th ASME Summer Bioengineering Conference, SBC2009 - Lake Tahoe, CA, United States
Duration: 17 Jun 200921 Jun 2009

Publication series

NameProceedings of the ASME Summer Bioengineering Conference 2009, SBC2009
NumberPART A

Conference

Conference11th ASME Summer Bioengineering Conference, SBC2009
Country/TerritoryUnited States
CityLake Tahoe, CA
Period17/06/0921/06/09

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