Tuning conformation and properties of peptidomimetic backbones through dual: N / C α-substitution

R. Kaminker*, I. Kaminker, W. R. Gutekunst, Y. Luo, S. Lee, J. Niu, S. Han, C. J. Hawker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We demonstrate that changing the backbone between peptides, peptoids and the underexplored dual N/Cα-substituted peptoids analogues allows for control over the preferred conformation of the intrinsically disordered biomimetic oligomers. The conformation tunability is directly probed using electron paramagnetic resonance (EPR), and is shown to manifest itself in differences in the nanoparticle-oligomer hybridization propensity.

Original languageEnglish
Pages (from-to)5237-5240
Number of pages4
JournalChemical Communications
Volume54
Issue number41
DOIs
StatePublished - 2018
Externally publishedYes

Funding

FundersFunder number
Materials Research Science and Engineering CentersDMR 1720256
Weizmann Institute of Science-National Postdoctoral Award for Advancing Women in Science
National Science Foundation
National Institutes of Health
National Institute of General Medical SciencesF32GM108323
Defense Advanced Research Projects Agency66001-14-2-4055
Human Frontier Science Program

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