Tunable Nanochannels Connected in Series for Dynamic Control of Multiple Concentration-Polarization Layers and Preconcentrated Molecule Plugs

Barak Sabbagh, Elad Stolovicki, Sinwook Park, David A. Weitz, Gilad Yossifon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Integration of ionic permselective medium (e.g., nanochannels, membranes) within microfluidic channels has been shown to enable on-chip desalination, sample purification, bioparticle sorting, and biomolecule concentration for enhanced detection sensitivity. However, the ion-permselective mediums are generally of fixed properties and cannot be dynamically tuned. Here we study a microfluidic device consisting of an array of individually addressable elastic membranes connected in series on top of a single microfluidic channel that can be deformed to locally reduce the channel cross-section into a nanochannel. Dynamic tunability of the ion-permselective medium, as well as controllability of its location and ionic permselectivity, introduces a new functionality to microfluidics-based lab-on-a-chip devices, for example, dynamic localization of preconcentrated biomolecule plugs at different sensing regions for multiplex detection. Moreover, the ability to simultaneously form a series of preconcentrated plugs at desired locations increases parallelization of the system and the trapping efficiency of target analytes.

Original languageEnglish
Pages (from-to)8524-8533
Number of pages10
JournalNano Letters
Volume20
Issue number12
DOIs
StatePublished - 9 Dec 2020
Externally publishedYes

Funding

FundersFunder number
Harvard University MRSECDMR-1420570
National Science Foundation1541959, DMR-1708729
Israel Science FoundationISF 1938/16

    Keywords

    • Electrokinetics
    • concentration-polarization
    • nanofluidics
    • pneumatic microvalve
    • preconcentration

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