TY - JOUR
T1 - Tunable hydroxyapatite wettability
T2 - Effect on adhesion of biological molecules
AU - Aronov, D.
AU - Rosen, R.
AU - Ron, E. Z.
AU - Rosenman, G.
N1 - Funding Information:
The authors are thankful to Prof. A. Karlov (COMM, Tomsk, Russian Federation) for development of the HAp nanopowder and Prof. G. Mezinskas (Institute of Silicate Materials, Riga Technical University, Riga, Latvia) for the HAp ceramics fabrication. This research was supported by the European Commission PROJECT NMP3-CT-504937 “PERCERAMICS”, by the Peikovski Valachi fellowship fund and by the Manja and Morris Leigh Chair of Biophysics and Biotechnology.
PY - 2006/12
Y1 - 2006/12
N2 - Surface wettability modifications of biocompatible materials and wettability patterning are attractive methods for directed biological cells immobilization for tissue engineering, drug delivery, gene transfer, etc. Hydroxyapatite is known as an implantable biomimetic material and a substrate for effective adhesion of biological cells of various origins. Here we report the use of a low-energy electron irradiation to achieve tunable wettability of the hydroxyapatite in a wide range of contact angles, from 10° to 100°, with accuracy of ±3°. The incident electrons generate electron/hole pairs resulting in significant variation of the surface potential of the hydroxyapatite semiconductor and give rise to pronounced wettability modification. Tailoring the gradually varied wettability state in the hydroxyapatite nanoceramics enabled the differential binding of biological materials with different surface properties, such as bovine serum albumin (BSA) and deoxyribonucleic acid (DNA).
AB - Surface wettability modifications of biocompatible materials and wettability patterning are attractive methods for directed biological cells immobilization for tissue engineering, drug delivery, gene transfer, etc. Hydroxyapatite is known as an implantable biomimetic material and a substrate for effective adhesion of biological cells of various origins. Here we report the use of a low-energy electron irradiation to achieve tunable wettability of the hydroxyapatite in a wide range of contact angles, from 10° to 100°, with accuracy of ±3°. The incident electrons generate electron/hole pairs resulting in significant variation of the surface potential of the hydroxyapatite semiconductor and give rise to pronounced wettability modification. Tailoring the gradually varied wettability state in the hydroxyapatite nanoceramics enabled the differential binding of biological materials with different surface properties, such as bovine serum albumin (BSA) and deoxyribonucleic acid (DNA).
KW - Adhesion molecule
KW - Hydroxyapatite
KW - Surface modification
KW - Wettability
UR - http://www.scopus.com/inward/record.url?scp=33750167571&partnerID=8YFLogxK
U2 - 10.1016/j.procbio.2006.06.006
DO - 10.1016/j.procbio.2006.06.006
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AN - SCOPUS:33750167571
SN - 1359-5113
VL - 41
SP - 2367
EP - 2372
JO - Process Biochemistry
JF - Process Biochemistry
IS - 12
ER -