Tumour bound immunoglobulins. The in vitro disappearance of immunoglobulin from the surface of coated tumour cells, and some properties of released components

M. Ran, F. Fish, I. P. Witz, G. Klein

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoglobulin coated ascites tumor cells lose some of their immunoglobulin coating following their transfer to in vitro culture conditions. The uncoating process is metabolism dependent and related to the turning over of cell surface components. Uncoated tumor cells bind globulin isolated from tumor eluates more efficiently than coated cells. Analysis of the spent medium of short term tumor cell cultures revealed the presence of both immunoglobulin and antigenic cell surface components.

Original languageEnglish
Pages (from-to)335-353
Number of pages19
JournalClinical and Experimental Immunology
Volume16
Issue number3
StatePublished - 1974

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