Immunoglobulin coated ascites tumor cells lose some of their immunoglobulin coating following their transfer to in vitro culture conditions. The uncoating process is metabolism dependent and related to the turning over of cell surface components. Uncoated tumor cells bind globulin isolated from tumor eluates more efficiently than coated cells. Analysis of the spent medium of short term tumor cell cultures revealed the presence of both immunoglobulin and antigenic cell surface components.
|Number of pages||19|
|Journal||Clinical and Experimental Immunology|
|State||Published - 1974|