Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)

S. Morecki; A. Nagler; Z. Zakay-Rones; M. Schlesinger; A. Lubina-Salomon; T. Pugatsch; Y. Moshel; S. Slavin

doi:10.1016/S0145-2126(98)00080-0

Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)

S. Morecki^*, A. Nagler, Z. Zakay-Rones, M. Schlesinger, A. Lubina-Salomon, T. Pugatsch, Y. Moshel, S. Slavin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.

Original language	English
Pages (from-to)	831-835
Number of pages	5
Journal	Leukemia Research
Volume	22
Issue number	9
DOIs	https://doi.org/10.1016/S0145-2126(98)00080-0
State	Published - Sep 1998
Externally published	Yes

Keywords

Cytokine gene transfer
Immunogenicity
Tumorigenicity
Viral infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0145-2126(98)00080-0

Cite this

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title = "Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)",

abstract = "Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.",

keywords = "Cytokine gene transfer, Immunogenicity, Tumorigenicity, Viral infection",

author = "S. Morecki and A. Nagler and Z. Zakay-Rones and M. Schlesinger and A. Lubina-Salomon and T. Pugatsch and Y. Moshel and S. Slavin",

note = "Funding Information: This research was done in Max Moss Leukemia Research Laboratory and was supported by a grant from the Israeli Cancer Association (Grant No. 930120-B to S. Morecki). We would also like to thank Baxter Healthcare Corporation for their financial support.",

year = "1998",

month = sep,

doi = "10.1016/S0145-2126(98)00080-0",

language = "אנגלית",

volume = "22",

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journal = "Leukemia Research",

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T1 - Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)

AU - Morecki, S.

AU - Nagler, A.

AU - Zakay-Rones, Z.

AU - Schlesinger, M.

AU - Lubina-Salomon, A.

AU - Pugatsch, T.

AU - Moshel, Y.

AU - Slavin, S.

N1 - Funding Information: This research was done in Max Moss Leukemia Research Laboratory and was supported by a grant from the Israeli Cancer Association (Grant No. 930120-B to S. Morecki). We would also like to thank Baxter Healthcare Corporation for their financial support.

PY - 1998/9

Y1 - 1998/9

N2 - Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.

AB - Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.

KW - Cytokine gene transfer

KW - Immunogenicity

KW - Tumorigenicity

KW - Viral infection

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VL - 22

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EP - 835

JO - Leukemia Research

JF - Leukemia Research

IS - 9

ER -

Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1)

Abstract

Keywords

UN SDGs

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