TY - JOUR
T1 - Tumor localization using magnetic nanoparticle-induced acoustic signals
AU - Tsalach, A.
AU - Steinberg, I.
AU - Gannot, I.
PY - 2014/8
Y1 - 2014/8
N2 - Cancer is a major public health problem worldwide, especially in developed countries. Early detection of cancer can greatly increase both survival rates and quality of life for patients. A magnetoacoustic-based method had been previously proposed for early tumor detection, in a minimal invasive procedure, using magnetic nanoparticles (MNPs). This paper presents a supporting localization algorithm that can provide the clinician with essential tumor location data and could enable a sequential biopsy. It provides localization algorithm development, as well as its validation in both computerized simulations and in vitro experiments. Three-dimensional (3-D) tumor localization is demonstrated with an error of 2.14 mm and an overlapping volume of 84% of the actual tumor. The obtained results are promising and prove the feasibility of tumor localization using a time difference of arrival algorithm along with a magnetoacoustic detection scheme.
AB - Cancer is a major public health problem worldwide, especially in developed countries. Early detection of cancer can greatly increase both survival rates and quality of life for patients. A magnetoacoustic-based method had been previously proposed for early tumor detection, in a minimal invasive procedure, using magnetic nanoparticles (MNPs). This paper presents a supporting localization algorithm that can provide the clinician with essential tumor location data and could enable a sequential biopsy. It provides localization algorithm development, as well as its validation in both computerized simulations and in vitro experiments. Three-dimensional (3-D) tumor localization is demonstrated with an error of 2.14 mm and an overlapping volume of 84% of the actual tumor. The obtained results are promising and prove the feasibility of tumor localization using a time difference of arrival algorithm along with a magnetoacoustic detection scheme.
KW - Cancer detection
KW - magnetic nanoparticles (MNPs)
KW - magnetoacoustics
UR - http://www.scopus.com/inward/record.url?scp=84904685136&partnerID=8YFLogxK
U2 - 10.1109/TBME.2013.2286638
DO - 10.1109/TBME.2013.2286638
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AN - SCOPUS:84904685136
SN - 0018-9294
VL - 61
SP - 2313
EP - 2323
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 8
M1 - 6642046
ER -