TY - JOUR
T1 - Tumor enhancing T lymphocytes in mice
T2 - Further studies on characteristics and mechanism of activity
AU - Small, Myra
PY - 1982/4/15
Y1 - 1982/4/15
N2 - In order to test the possibility that tumor‐enhancing T lymphocytes can suppress other lymphoid cells, such as those with anti‐tumor activity, their effect was tested in an allogeneic response of cell‐mediated lysis. Normal thy‐mocytes and spleen cells from mice with advanced tumors, two populations which enhance the growth of solid tumors, both suppressed the generation of CML. Since these results suggest that the mechanism of enhancement by T cells may resemble suppression in other immune responses, we looked for Fc receptors on the sensitized cells involved in tumor enhancement Cells expressing Fc receptors appeared to be necessary for enhancement of tumor growth to occur.
AB - In order to test the possibility that tumor‐enhancing T lymphocytes can suppress other lymphoid cells, such as those with anti‐tumor activity, their effect was tested in an allogeneic response of cell‐mediated lysis. Normal thy‐mocytes and spleen cells from mice with advanced tumors, two populations which enhance the growth of solid tumors, both suppressed the generation of CML. Since these results suggest that the mechanism of enhancement by T cells may resemble suppression in other immune responses, we looked for Fc receptors on the sensitized cells involved in tumor enhancement Cells expressing Fc receptors appeared to be necessary for enhancement of tumor growth to occur.
UR - http://www.scopus.com/inward/record.url?scp=0020032927&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910290417
DO - 10.1002/ijc.2910290417
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AN - SCOPUS:0020032927
SN - 0020-7136
VL - 29
SP - 465
EP - 469
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 4
ER -