Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

Yaron Carmi, Tyler Prestwood, Edgar G. Engleman

Research output: Contribution to journalArticlepeer-review

Abstract

The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key. In the absence of dendritic cell (DC) stimulation, such antibodies provide little benefit, but in a stimulatory context they can initiate potent antitumor immunity.

Original languageEnglish
Article numbere1078063
JournalOncoImmunology
Volume8
Issue number10
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Dendritic cells
  • Fc receptors
  • Tumor-binding antibodies

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