Tulearins A, B, and C; structures and absolute configurations

Ashgan Bishara, Amira Rudi, Israel Goldberg, Maurice Aknin, Yoel Kashman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The relative configuration of tulearin A (1) is determined by X-ray diffraction analysis of a cyclic carbonate derivative 2 and the absolute configuration (2R,3R,5S,8S,9S,15R,17S) from the 9-MTPA-esters 1R and 1S is determined using the modified Mosher's method. A mechanism for the unexpected formation of carbonate 2 is suggested. Two N-phenyltriazolinedione derivatives 3 and 4 are also prepared. Two additional tulearins, B and C (5 and 6) are isolated in very small amounts and their structures are elucidated by spectroscopic means.

Original languageEnglish
Pages (from-to)3820-3822
Number of pages3
JournalTetrahedron Letters
Issue number27
StatePublished - 8 Jul 2009


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