Tubulin microheterogeneity increases with rat brain maturation [22]

Illana Gozes*, Uriel Z. Littauer

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

Abstract

MICROTUBULES are present in all eukaryotic cells and have been found to have a variety of structural and dynamic roles in cell shape, division, motility, transport and secretion1. In nervous tissue neurite outgrowth and axoplasmic transport are also thought to depend on microtubule integrity2. The micro-tubule subunit protein, tubulin, is a heterodimer composed of two polypeptides α and β (refs 3,4). The α and β subunits show microheterogeneity and both have been resolved into two or three components5-8. The question therefore arises as to whether changes occur in the relative proportions of the multiple forms of tubulin upon assumption of different roles within the nerve cell. We show here that cytoplasmic rat brain tubulin, as resolved by isoelectric focusing, is highly heterogeneous. Moreover, tubulin microheterogeneity seems to be developmentally determined, increasing from seven to nine distinct components during early postnatal rat brain maturation. However, extensive tubulin microheterogeneity is prominent in the brain, as tubulin from other organs is less heterogeneous.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalNature
Volume276
Issue number5686
DOIs
StatePublished - 1978
Externally publishedYes

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