Tube feeding with a diabetes-specific feed for 12 weeks improves glycaemic control in type 2 diabetes patients

Nachum Vaisman*, Mirian Lansink, Carlette H. Rouws, Katrien M. van Laere, R. Segal, Eva Niv, Tim E. Bowling, Dan L. Waitzberg, John E. Morley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Assess longer-term (12 weeks) effects of a diabetes-specific feed on postprandial glucose response, glycaemic control (HbA1c), lipid profile, (pre)-albumin, clinical course and tolerance in diabetic patients. Methods: In this randomized, controlled, double-blind, parallel group study 25 type 2 diabetic patients on tube feeding were included. Patients received a soy-protein based, multi-fibre diabetes-specific feed or isocaloric, fibre-containing standard feed for 12 weeks, while continuing on their anti-diabetic medication. At the beginning, after 6 and 12 weeks, several (glycaemic) parameters were assessed. Results: The postprandial glucose response (iAUC) to the diabetes-specific feed was lower at the 1st assessment compared with the standard feed (p = 0.008) and this difference did not change over time. HbA1c decreased over time in the diabetes-specific and not in the standard feed group (treatment*time:p = 0.034): 6.9 ± 0.3% (mean ± SEM) at baseline vs. 6.2 ± 0.4% at 12 weeks in the diabetes-specific group compared to 7.9 ± 0.3% to 8.7 ± 0.4% in the standard feed group. No significant treatment*time effect was found for fasting glucose, insulin, (pre-) albumin or lipid profile, except for increase of HDL in the diabetes-specific group. Conclusions: The diabetes-specific feed studied significantly improved longer-term glycaemic control in diabetic patients. This was achieved in addition to on-going anti-diabetic medication and may affect clinical outcome.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalClinical Nutrition
Volume28
Issue number5
DOIs
StatePublished - Oct 2009
Externally publishedYes

Funding

FundersFunder number
Danone Research Centre for Specialised Nutrition

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