@article{4236965243974721b6f7ceb1cd2e17aa,
title = "Tryptophan-glucosamine conjugates modulate tau-derived PHF6 aggregation at low concentrations",
abstract = "Glycosylation of amyloidogenic proteins enhances their solubility and reduces propensity for aggregation. We therefore, prepared tryptophan-glucosamine conjugates to modulate aggregation of tau-derived PHF6-peptide. Combined in vitro and in silico approaches indicated that these conjugates inhibited oligomerization and fibril formation of PHF6 and disrupted its preformed fibrils at very low concentration. These effects mainly arise from the glucopyranoside moiety.",
author = "Ashim Paul and Li, {Wen Hao} and Viswanathan, {Guru Krishna Kumar} and Elad Arad and Satabdee Mohapatra and Gao Li and Raz Jelinek and Ehud Gazit and Li, {Yan Mei} and Daniel Segal",
note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
doi = "10.1039/c9cc06868f",
language = "אנגלית",
volume = "55",
pages = "14621--14624",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "97",
}