@article{69460715126e4b54a76a26645f6ec258,
title = "Trinucleotide repeats are prevalent among cancer-related genes",
abstract = "Trinucleotide repeats (TNRs) have been primarily connected to neurologic and neuromuscular diseases, with few specific TNRs linked with various tumors. Here we conduct a genome-wide analysis and show that TNRs are five times more prevalent in cancer-related human genes. Interestingly, we also find that cancer-related genes are significantly longer than other genes. Our results suggest that genes containing TNRs are more prone to mutagenesis. The database of TNR genes can be used as a list of candidate cancer-related genes.",
author = "Yael Haberman and Ninette Amariglio and Gideon Rechavi and Eli Eisenberg",
note = "Funding Information: The authors thank E.Y. Levanon for many helpful comments and suggestions and for critical reading of the manuscript. Y.H. is supported by the Foulkes Foundation fellowship for MD-PhD students. G.R. holds the Djerassi Chair in Oncology at the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. The authors also thank the Paamei Tikva fund for their generous support of our research. E.E. is supported by an Alon fellowship at Tel-Aviv University. ",
year = "2008",
month = jan,
doi = "10.1016/j.tig.2007.09.005",
language = "אנגלית",
volume = "24",
pages = "14--18",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Ltd.",
number = "1",
}
