Trinucleotide repeats are prevalent among cancer-related genes

Yael Haberman, Ninette Amariglio, Gideon Rechavi, Eli Eisenberg

Research output: Contribution to journalShort surveypeer-review

Abstract

Trinucleotide repeats (TNRs) have been primarily connected to neurologic and neuromuscular diseases, with few specific TNRs linked with various tumors. Here we conduct a genome-wide analysis and show that TNRs are five times more prevalent in cancer-related human genes. Interestingly, we also find that cancer-related genes are significantly longer than other genes. Our results suggest that genes containing TNRs are more prone to mutagenesis. The database of TNR genes can be used as a list of candidate cancer-related genes.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalTrends in Genetics
Volume24
Issue number1
DOIs
StatePublished - Jan 2008

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