Trimodal nanoparticle contrast agent for CT, MRI and SPECT imaging: Synthesis and characterization of radiolabeled core/shell iron oxide@gold nanoparticles

Menachem Motiei, Tamar Dreifuss, Tamar Sadan, Noam Omer, Tamar Blumenfeld-Katzir, Eirini Fragogeorgi, George Loudos, Rachela Popovtzer*, Noam Ben-Eliezer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, nanoparticles have emerged as promising contrast agents for various imaging applications. In this paper, we present the synthesis and characterization of a novel hybrid nano-struc-ture, consisting of an iron oxide@gold nanoparticle, labeled with technetium-99m, for trimodal SPECT/CT/MRI imaging. The particles showed efficient capabilities as CT/MRI imaging agent and high radiochemical yield, indicating a potential single hybrid material for multimodal SPECT/CT/MRI.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalChemistry Letters
Volume48
Issue number3
DOIs
StatePublished - 2019

Funding

FundersFunder number
Horizon 2020 Framework Programme
Stavros Niarchos Foundation
Centre National de la Recherche Scientifique
Ministry of Science and Technology, Israel
Horizon 2020761031

    Keywords

    • Core/shell nanoparticles
    • Multimodal imaging
    • Nanoparticle contrast agents

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