TY - JOUR
T1 - TRIIODOTHYRONINE AND THYROID-STIMULATING HORMONE RESPONSE TO THYROTROPHIN-RELEASING HORMONE. A NEW TEST OF THYROIDAL AND PITUITARY RESERVE
AU - Shenkman, Louis
AU - Suphavai, Araya
AU - Mitsuma, Terunori
AU - Hollander, Charles S.
N1 - Funding Information:
The authors express their thanks to Dr. Michael Anderson for providing the thyrotrophin-releasing hormone and to Colette Thaw, Nadel, John expert assistance.Harriet and Colucci for technical This work was supported by U.S.P.H.S. grants 5156-01, 2 R01-AM 14314-02, 03, and Fr 96. Requests for reprints should be addressed to L. S., Endocrine Unit, Department of Medicine, New York School of Medicine, 550 First Avenue, New York, New York 10016, U.S.A.
PY - 1972/1/15
Y1 - 1972/1/15
N2 - Intravenous administration of thyrotrophin-releasing hormone (T.R.H.) induces a prompt rise in immunoassayable thyroid-stimulating hormone (T.S.H.) and triiodothyronine (T3) in normal man. Basal T.S.H. levels are high in primary hypothyroidism and rise dramatically after T.R.H. In patients with hypothyroidism secondary to pituitary disease basal T.S.H. levels are low and show no increase with T.R.H. In contrast, 2 patients with hypothalamic hypothyroidism had nil basal levels of T.S.H., which rose normally after T.R.H. administration. Basal T3 levels were low in all forms of hypothyroidism and did not rise after T.R.H. administration. The failure of T3 to increase normally after T.R.H. in the 2 patients with hypothalamic hypothyroidism in the face of a normal T.S.H. stimulation test suggests a diminished thyroidal reserve in these patients. Intravenous T.R.H. administration may prove of value in the simultaneous assessment of pituitary and thyroidal reserve.
AB - Intravenous administration of thyrotrophin-releasing hormone (T.R.H.) induces a prompt rise in immunoassayable thyroid-stimulating hormone (T.S.H.) and triiodothyronine (T3) in normal man. Basal T.S.H. levels are high in primary hypothyroidism and rise dramatically after T.R.H. In patients with hypothyroidism secondary to pituitary disease basal T.S.H. levels are low and show no increase with T.R.H. In contrast, 2 patients with hypothalamic hypothyroidism had nil basal levels of T.S.H., which rose normally after T.R.H. administration. Basal T3 levels were low in all forms of hypothyroidism and did not rise after T.R.H. administration. The failure of T3 to increase normally after T.R.H. in the 2 patients with hypothalamic hypothyroidism in the face of a normal T.S.H. stimulation test suggests a diminished thyroidal reserve in these patients. Intravenous T.R.H. administration may prove of value in the simultaneous assessment of pituitary and thyroidal reserve.
UR - http://www.scopus.com/inward/record.url?scp=0015506923&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(72)90677-0
DO - 10.1016/S0140-6736(72)90677-0
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AN - SCOPUS:0015506923
SN - 0140-6736
VL - 299
SP - 111
EP - 113
JO - The Lancet
JF - The Lancet
IS - 7742
ER -