Triglyceride levels and risk of type 2 diabetes mellitus: A longitudinal large study

Amani Beshara*, Eytan Cohen, Elad Goldberg, Pearl Lilos, Moshe Garty, Ilan Krause

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglycemic participants.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalJournal of Investigative Medicine
Issue number2
StatePublished - Feb 2016


  • Diabetes Mellitus


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