Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China

Qiqi Wang; Yun Li; Yanming Li; Nir Osherov; Gustavo H. Goldman; Paul E. Verweij; Bo Zheng; Ruoyu Li; Wei Chen; Tianyu Liang; Zhe Wan; Wei Liu

doi:10.1080/22221751.2022.2076614

Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China

Qiqi Wang, Yun Li, Yanming Li, Nir Osherov, Gustavo H. Goldman, Paul E. Verweij, Bo Zheng, Ruoyu Li, Wei Chen, Tianyu Liang, Zhe Wan, Wei Liu^*

^*Corresponding author for this work

Clinical Microbiology and Immunology

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6 Scopus citations

Abstract

Aspergillus luchuensis, an industrially important member of Aspergillus species belonging to section Nigri used in fermentation in East Asia, was isolated from an immunocompromised patient with probable invasive pulmonary aspergillosis who failed voriconazole therapy in China. This isolate showed non-wild-type susceptibility to itraconazole, voriconazole, isavuconazole, and posaconazole. A G1378A mutation in cyp51A, resulting in the G441S amino acid substitution, which is the homolog to G448S conferring triazole-resistance in A. fumigatus, was detected in the A. luchuensis isolate.

Original language	English
Pages (from-to)	1435-1438
Number of pages	4
Journal	Emerging Microbes and Infections
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/22221751.2022.2076614
State	Published - 2022

Keywords

Aspergillus luchuensis
aspergillosis
cyp51A mutation
fermentation in East Asia
triazole-resistance

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10.1080/22221751.2022.2076614

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Wang, Q., Li, Y., Li, Y., Osherov, N., Goldman, G. H., Verweij, P. E., Zheng, B., Li, R., Chen, W., Liang, T., Wan, Z., & Liu, W. (2022). Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China. Emerging Microbes and Infections, 11(1), 1435-1438. https://doi.org/10.1080/22221751.2022.2076614

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title = "Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China",

abstract = "Aspergillus luchuensis, an industrially important member of Aspergillus species belonging to section Nigri used in fermentation in East Asia, was isolated from an immunocompromised patient with probable invasive pulmonary aspergillosis who failed voriconazole therapy in China. This isolate showed non-wild-type susceptibility to itraconazole, voriconazole, isavuconazole, and posaconazole. A G1378A mutation in cyp51A, resulting in the G441S amino acid substitution, which is the homolog to G448S conferring triazole-resistance in A. fumigatus, was detected in the A. luchuensis isolate.",

keywords = "Aspergillus luchuensis, aspergillosis, cyp51A mutation, fermentation in East Asia, triazole-resistance",

author = "Qiqi Wang and Yun Li and Yanming Li and Nir Osherov and Goldman, {Gustavo H.} and Verweij, {Paul E.} and Bo Zheng and Ruoyu Li and Wei Chen and Tianyu Liang and Zhe Wan and Wei Liu",

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year = "2022",

doi = "10.1080/22221751.2022.2076614",

language = "אנגלית",

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Wang, Q, Li, Y, Li, Y, Osherov, N, Goldman, GH, Verweij, PE, Zheng, B, Li, R, Chen, W, Liang, T, Wan, Z & Liu, W 2022, 'Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China', Emerging Microbes and Infections, vol. 11, no. 1, pp. 1435-1438. https://doi.org/10.1080/22221751.2022.2076614

Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China. / Wang, Qiqi; Li, Yun; Li, Yanming et al.
In: Emerging Microbes and Infections, Vol. 11, No. 1, 2022, p. 1435-1438.

Research output: Contribution to journal › Letter › peer-review

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T1 - Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China

AU - Wang, Qiqi

AU - Li, Yun

AU - Li, Yanming

AU - Osherov, Nir

AU - Goldman, Gustavo H.

AU - Verweij, Paul E.

AU - Zheng, Bo

AU - Li, Ruoyu

AU - Chen, Wei

AU - Liang, Tianyu

AU - Wan, Zhe

AU - Liu, Wei

PY - 2022

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AB - Aspergillus luchuensis, an industrially important member of Aspergillus species belonging to section Nigri used in fermentation in East Asia, was isolated from an immunocompromised patient with probable invasive pulmonary aspergillosis who failed voriconazole therapy in China. This isolate showed non-wild-type susceptibility to itraconazole, voriconazole, isavuconazole, and posaconazole. A G1378A mutation in cyp51A, resulting in the G441S amino acid substitution, which is the homolog to G448S conferring triazole-resistance in A. fumigatus, was detected in the A. luchuensis isolate.

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KW - aspergillosis

KW - cyp51A mutation

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Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China

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