Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China

Qiqi Wang, Yun Li, Yanming Li, Nir Osherov, Gustavo H. Goldman, Paul E. Verweij, Bo Zheng, Ruoyu Li, Wei Chen, Tianyu Liang, Zhe Wan, Wei Liu*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

Aspergillus luchuensis, an industrially important member of Aspergillus species belonging to section Nigri used in fermentation in East Asia, was isolated from an immunocompromised patient with probable invasive pulmonary aspergillosis who failed voriconazole therapy in China. This isolate showed non-wild-type susceptibility to itraconazole, voriconazole, isavuconazole, and posaconazole. A G1378A mutation in cyp51A, resulting in the G441S amino acid substitution, which is the homolog to G448S conferring triazole-resistance in A. fumigatus, was detected in the A. luchuensis isolate.

Original languageEnglish
Pages (from-to)1435-1438
Number of pages4
JournalEmerging Microbes and Infections
Volume11
Issue number1
DOIs
StatePublished - 2022

Funding

FundersFunder number
National Natural Science Foundation of China81971912, 81861148028
National Key Research and Development Program of China2021YFC2300400

    Keywords

    • Aspergillus luchuensis
    • aspergillosis
    • cyp51A mutation
    • fermentation in East Asia
    • triazole-resistance

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