TRH stimulation test in obsessive-compulsive patients

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Serum thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) levels were measured before and after stimulation with 200 μg of thyrotropin releasing hormone (TRH) in 10 patients with obsessive-compulsive disorder (OCD) and in 10 control subjects. There were significantly more blunted TSH responses among OCD patients than control subjects. PRL and GH responses to TRH challenge did not differ between OCD patients and controls. These results may indicate dysregulation of the hypothalamic-pituitary-thyroid axis in OCD.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalPsychiatry Research
Issue number1
StatePublished - Jul 1991


  • Obsessive-compulsive disorder
  • growth hormone
  • prolactin
  • thyrotropin
  • thyrotropin releasing hormone


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