TRH stimulation test in obsessive-compulsive patients

Dov Aizenberg; Haggai Hermesh; Irit Gil-ad; Hanan Munitz; Sam Tyano; Zvi Laron; Abraham Weizman

doi:10.1016/0165-1781(91)90049-U

TRH stimulation test in obsessive-compulsive patients

Dov Aizenberg, Haggai Hermesh, Irit Gil-ad, Hanan Munitz, Sam Tyano, Zvi Laron, Abraham Weizman

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Serum thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) levels were measured before and after stimulation with 200 μg of thyrotropin releasing hormone (TRH) in 10 patients with obsessive-compulsive disorder (OCD) and in 10 control subjects. There were significantly more blunted TSH responses among OCD patients than control subjects. PRL and GH responses to TRH challenge did not differ between OCD patients and controls. These results may indicate dysregulation of the hypothalamic-pituitary-thyroid axis in OCD.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Psychiatry Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(91)90049-U
State	Published - Jul 1991

Keywords

Obsessive-compulsive disorder
growth hormone
prolactin
thyrotropin
thyrotropin releasing hormone

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10.1016/0165-1781(91)90049-U

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abstract = "Serum thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) levels were measured before and after stimulation with 200 μg of thyrotropin releasing hormone (TRH) in 10 patients with obsessive-compulsive disorder (OCD) and in 10 control subjects. There were significantly more blunted TSH responses among OCD patients than control subjects. PRL and GH responses to TRH challenge did not differ between OCD patients and controls. These results may indicate dysregulation of the hypothalamic-pituitary-thyroid axis in OCD.",

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AU - Gil-ad, Irit

AU - Munitz, Hanan

AU - Tyano, Sam

AU - Laron, Zvi

AU - Weizman, Abraham

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AB - Serum thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) levels were measured before and after stimulation with 200 μg of thyrotropin releasing hormone (TRH) in 10 patients with obsessive-compulsive disorder (OCD) and in 10 control subjects. There were significantly more blunted TSH responses among OCD patients than control subjects. PRL and GH responses to TRH challenge did not differ between OCD patients and controls. These results may indicate dysregulation of the hypothalamic-pituitary-thyroid axis in OCD.

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TRH stimulation test in obsessive-compulsive patients

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