Treatment with low-dose, single-agent belantamab mafodotin is safe and provides long-term responses in heavily pretreated multiple myeloma patients

Objectives: To evaluate whether low-dose belantamab mafodotin (B-MAF) dosing results in lower toxicity and better overall outcome. Methods: We retrospectively evaluated nine consecutive patients treated with low-dose (1.9 mg/kg) B-MAF. Results: The median age was 70 years. Most patients were penta-refractory. Ocular toxicity was observed in 77.7%. Adverse events resulting in treatment delays were recorded in 9 out of 124 cycles being given. Overall response rate was 66% (6/9), and all responding patients achieved very good partial response or better. Within a median follow-up of 12 (range 0.5–13.8) months, median progression-free survival and overall survival were 14 (CI95% 6–22) and 20 (95%CI 0–41) months, respectively. Conclusion: Low-dose B-MAF regimen showed high-efficacy and low-toxicity profile.