TY - JOUR
T1 - Treatment responsiveness in CIDP patients with diabetes is associated with higher degrees of demyelination
AU - Abraham, Alon
AU - Alabdali, Majed
AU - Qrimli, Mohammad
AU - Albulaihe, Hana
AU - Breiner, Ari
AU - Barnett, Carolina
AU - Katzberg, Hans D.
AU - Lovblom, Leif E.
AU - Perkins, Bruce A.
AU - Bril, Vera
N1 - Publisher Copyright:
© 2015 Abraham et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2015/10/13
Y1 - 2015/10/13
N2 - Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is one of several chronic treatable acquired demyelinating neuropathies. Objectives: To explore the association between the degree of demyelination in CIDP, and treatment responsiveness. Methods: A retrospective chart review of CIDP subjects assessed between 1997 and 2013 was performed to compare treatment responsiveness using different sets of criteria. Results: 99 CIDP patients were included, 34 with diabetes mellitus (DM). Treatment responsiveness was higher in CIDP-DM fulfilling 1 or more EFNS/PNS criteria, (63% vs. 31%, p = 0.03), and in CIDP+DM fulfilling 2 or more criteria (89% vs. 36%, p = 0.01). Nonetheless, treatment responsiveness in CIDP+DM had the highest odds ratio (3.73, p = 0.01). Similar results were also shown in simplified uniform study criteria, with 10% cut off values for CIDP-DM, compared to 30% for CIDP+DM. Conclusion: In CIDP+DM, higher degrees of demyelination are associated with treatment responsiveness, implying the need to adjust current criteria in these patients.
AB - Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is one of several chronic treatable acquired demyelinating neuropathies. Objectives: To explore the association between the degree of demyelination in CIDP, and treatment responsiveness. Methods: A retrospective chart review of CIDP subjects assessed between 1997 and 2013 was performed to compare treatment responsiveness using different sets of criteria. Results: 99 CIDP patients were included, 34 with diabetes mellitus (DM). Treatment responsiveness was higher in CIDP-DM fulfilling 1 or more EFNS/PNS criteria, (63% vs. 31%, p = 0.03), and in CIDP+DM fulfilling 2 or more criteria (89% vs. 36%, p = 0.01). Nonetheless, treatment responsiveness in CIDP+DM had the highest odds ratio (3.73, p = 0.01). Similar results were also shown in simplified uniform study criteria, with 10% cut off values for CIDP-DM, compared to 30% for CIDP+DM. Conclusion: In CIDP+DM, higher degrees of demyelination are associated with treatment responsiveness, implying the need to adjust current criteria in these patients.
UR - http://www.scopus.com/inward/record.url?scp=84948808392&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0139674
DO - 10.1371/journal.pone.0139674
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C2 - 26461125
AN - SCOPUS:84948808392
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e0139674
ER -
