Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid

Rivka H. Regev, Orit Stolar, Aryeh Raz, Tzipora Dolfin

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of Dubin-Johnson Syndrome in a neonate presenting with severe direct hyperbilirubinemia, which failed to respond to phenobarbital treatment. Ursodeoxycholic Acid added to therapy was well tolerated, and resulted in declining bilirubin concentration. We suggest ursodeoxycholic acid in treatment for Dubin-Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalJournal of Perinatal Medicine
Volume30
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Cholestatic jaundice
  • Neonatal Dubin-Johnson syndrome
  • Ursodeoxycholic acid

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