Treatment of Ruptured Interventricular Septum With Afterload Reduction

Elio Disegni, Elieser Kaplinsky, Herman O. Klein, Maurice Levy

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Two patients with a ruptured interventricular septum complicating acute myocardial infarction were treated with isosorbide dinitrate. The first patient recovered from cardiogenic shock after sublingual administration of 5 mg of isosorbide dinitrate every two hours and was successfully operated on. The second patient recovered from severe pulmonary edema during the acute stage of the infarction with sublingual isosorbide dinitrate. Moreover, she experienced a considerable symptomatic improvement when a 5 mg sublingual dose of isosorbide dinitrate every three hours was added to her long-term treatment. Analysis of hemodynamic data showed that the most striking change following administration of the drug was the substantial reduction of pulmonary wedge pressure. The striking symptomatic and hemodynamic improvement was achieved by the favorable effect of afterload reduction on left ventricular performance and not by reduction in left to right shunt.

Original languageEnglish
Pages (from-to)1427-1429
Number of pages3
JournalArchives of Internal Medicine
Issue number9
StatePublished - Sep 1978
Externally publishedYes


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