Treatment of respiratory damage in mice by aerosols of drug-encapsulating targeted lipid-based particles

Ilia Rivkin, Yifat Galnoy-Glucksam, Inbar Elron-Gross, Amichay Afriat, Arik Eisenkraft, Rimona Margalit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The purpose of this study was to develop a treatment for respiratory damage caused by exposure to toxic industrial chemicals (TICs), including mass casualty events, by aerosols of dexamethasone and/or N-acetyl cysteine formulated in targeted lipid-based particles. Good encapsulation, performance as slow-release drug depots, conservation of matter, and retention of biological activity were obtained for the three drug-carrier formulations, pre- and post-aerosolization. Weight changes over a 2 week period were applied, deliberately, as a non-invasive clinical parameter. Control mice gained weight continuously, whereas a non-lethal 30 minute exposure of mice to 300 ppm Cl2 in air showed a two-trend response. Weight loss over the first two days, reversing thereafter to weight gain, but at a rate and level significantly slower and smaller than those of the control mice, indicating the chlorine damage was long-term. The weight changes of Cl2-exposed mice given the inhalational treatments also showed the two-trend response, but the weight gain rates and levels were similar to those of the control mice, reaching the weight-gain range of the control mice. Following this proof of concept, studies are now extended to include additional TICs, and biochemical markers of injury and recovery.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalJournal of Controlled Release
Volume257
DOIs
StatePublished - 10 Jul 2017

Keywords

  • Aerosols
  • Mass casualty events
  • Respiratory damage
  • TIC exposure

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