TY - JOUR
T1 - Treatment of respiratory damage in mice by aerosols of drug-encapsulating targeted lipid-based particles
AU - Rivkin, Ilia
AU - Galnoy-Glucksam, Yifat
AU - Elron-Gross, Inbar
AU - Afriat, Amichay
AU - Eisenkraft, Arik
AU - Margalit, Rimona
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2017/7/10
Y1 - 2017/7/10
N2 - The purpose of this study was to develop a treatment for respiratory damage caused by exposure to toxic industrial chemicals (TICs), including mass casualty events, by aerosols of dexamethasone and/or N-acetyl cysteine formulated in targeted lipid-based particles. Good encapsulation, performance as slow-release drug depots, conservation of matter, and retention of biological activity were obtained for the three drug-carrier formulations, pre- and post-aerosolization. Weight changes over a 2 week period were applied, deliberately, as a non-invasive clinical parameter. Control mice gained weight continuously, whereas a non-lethal 30 minute exposure of mice to 300 ppm Cl2 in air showed a two-trend response. Weight loss over the first two days, reversing thereafter to weight gain, but at a rate and level significantly slower and smaller than those of the control mice, indicating the chlorine damage was long-term. The weight changes of Cl2-exposed mice given the inhalational treatments also showed the two-trend response, but the weight gain rates and levels were similar to those of the control mice, reaching the weight-gain range of the control mice. Following this proof of concept, studies are now extended to include additional TICs, and biochemical markers of injury and recovery.
AB - The purpose of this study was to develop a treatment for respiratory damage caused by exposure to toxic industrial chemicals (TICs), including mass casualty events, by aerosols of dexamethasone and/or N-acetyl cysteine formulated in targeted lipid-based particles. Good encapsulation, performance as slow-release drug depots, conservation of matter, and retention of biological activity were obtained for the three drug-carrier formulations, pre- and post-aerosolization. Weight changes over a 2 week period were applied, deliberately, as a non-invasive clinical parameter. Control mice gained weight continuously, whereas a non-lethal 30 minute exposure of mice to 300 ppm Cl2 in air showed a two-trend response. Weight loss over the first two days, reversing thereafter to weight gain, but at a rate and level significantly slower and smaller than those of the control mice, indicating the chlorine damage was long-term. The weight changes of Cl2-exposed mice given the inhalational treatments also showed the two-trend response, but the weight gain rates and levels were similar to those of the control mice, reaching the weight-gain range of the control mice. Following this proof of concept, studies are now extended to include additional TICs, and biochemical markers of injury and recovery.
KW - Aerosols
KW - Mass casualty events
KW - Respiratory damage
KW - TIC exposure
UR - http://www.scopus.com/inward/record.url?scp=84964407284&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2016.03.039
DO - 10.1016/j.jconrel.2016.03.039
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AN - SCOPUS:84964407284
SN - 0168-3659
VL - 257
SP - 163
EP - 169
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -