TY - CHAP
T1 - Treatment of resistant bacterial infections in children
T2 - Thinking inside and outside the box
AU - Livni, Gilat
AU - Ashkenazi, Shai
PY - 2013
Y1 - 2013
N2 - Antimicrobial resistance of bacteria causing pediatric infections has become more common and complicated in recent years. Although formerly confined to hospital settings, multi-drug resistant bacteria now also cause community-acquired infections. Treatment of infections caused by resistant pathogens is difficult, necessitating thinking both inside and outside the box. Determination of the precise minimal inhibitory concentration (MIC) is often crucial for selecting the most appropriate antibiotics, their doses, and use of prolonged infusions. For some multiply-resistant bacteria, off-label use of antibiotics, sometimes with no evidence from controlled studies ("salvage therapy") is unavoidable.
AB - Antimicrobial resistance of bacteria causing pediatric infections has become more common and complicated in recent years. Although formerly confined to hospital settings, multi-drug resistant bacteria now also cause community-acquired infections. Treatment of infections caused by resistant pathogens is difficult, necessitating thinking both inside and outside the box. Determination of the precise minimal inhibitory concentration (MIC) is often crucial for selecting the most appropriate antibiotics, their doses, and use of prolonged infusions. For some multiply-resistant bacteria, off-label use of antibiotics, sometimes with no evidence from controlled studies ("salvage therapy") is unavoidable.
UR - http://www.scopus.com/inward/record.url?scp=84873589034&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-4726-9_9
DO - 10.1007/978-1-4614-4726-9_9
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C2 - 23654061
AN - SCOPUS:84873589034
SN - 9781461447252
T3 - Advances in Experimental Medicine and Biology
SP - 123
EP - 132
BT - Hot Topics in Infection and Immunity in Children IX
PB - Springer Science and Business Media, LLC
ER -
