Treatment of Rapid Progression of Myopia: Case Series and Literature Review

Nir Erdinest, Naomi London*, Nadav Levinger, Itay Lavy, Eran Pras, Yair Morad

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


This retrospective case series demonstrates the combination of 0.05% atropine with MiSight® 1 day (Cooper vision, Sar Ramon, CA, USA) in rapid progression of myopia of 4 children. MiSight ® 1 day is a peripheral defocus, center-distance soft contact lens and is effective at controlling moderate progression of myopia during the course of 1 year. The current case series included 2 females and 2 males with an average age of 9.68 ± 0.26 years and an average axial length of 24.81 ± 0.92 mm. Their myopic progression during the previous year was -1.45 ± 0.27 D. The children had not attempted any myopia control thus far. This relatively high increase prompted a combination treatment of daily instillation of 0.05% atropine and MiSight, a daily replacement soft contact lens. Cycloplegic refraction and a slit-lamp evaluation were performed every 6 months to confirm no adverse reactions or staining was present. The 8-item contact lens dry eye questionnaire (CLDEQ-8) score of these children was 10.66 ± 1.52. The average myopia progression at the end of 1 year decreased to -0.41 ± 0.11 D, and the average axial length increase was 0.28 ± 0.08 mm. To the best of the authors' knowledge, this is the first published study showing a combination of 0.05% atropine and peripheral defocus soft contact lenses indicating efficacy at controlling moderate myopia progression.

Original languageEnglish
Pages (from-to)875-881
Number of pages7
JournalCase Reports in Ophthalmology
Issue number3
StatePublished - 1 Nov 2021
Externally publishedYes


FundersFunder number
Hadassah-Hebrew University Medical Center
Azrieli Foundation


    • Atropine
    • Myopia control
    • Myopia progression
    • Peripheral defocus
    • Soft contact lenses


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