Treatment of peri-implantitis using multiple applications of chlorhexidine chips: A double-blind, randomized multi-centre clinical trial

Eli E. Machtei*, Shai Frankenthal, Guy Levi, Rina Elimelech, Eyal Shoshani, Olivia Rosenfeld, Nirit Tagger-Green, Benjamin Shlomi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background Universal strategies for managing peri-implantitis are yet to be adopted. The aim of this study is to examine a protocol of intensive application of chlorhexidine containing chips in sites with peri-implantitis. Materials and Methods This multi-centre, randomized, double-blind, parallel, two-arm clinical trial included 60 patients (77 implants) with probing depth (PD) 6-10 mm and bone loss ≥2 mm around 1-2 implants. One to two weeks following SRP, baseline measurements were made followed by implants' debridement. Patients were randomized to receive matrix chips (MatrixC) or chlorhexidine Chips (PerioC). Measurements and chips placement were repeated at weeks 2, 4, 6, 8, 12 and 18. At 6 months, patients returned for final examination. Results Probing depth reduction was greater in the PerioC (2.19 ± 0.24 mm) compared with MatrixC (1.59 ± 0.23 mm), p = 0.07. Seventy percentage of the implants in the PerioC and 54% in the MatrixC had PD reduction ≥ 2 mm. Likewise, 40% of the sites (PerioC) and 24% (MatrixC) had PD reduction ≥ 3 mm. Clinical attachment level gains for both groups were significant; however, the changes in the PerioC group were significantly greater than in MatrixC [2.21 ± 0.23 mm. and 1.56 ± 0.25 mm respectively, p = 0.05]. Bleeding on probing was reduced by half in both groups. Conclusion Frequent placement of PerioC and MatrixC together with implants debridement resulted in a substantial improvement in sites with peri-implantitis. Further studies will be required to fully appreciate the mechanism of this treatment.

Original languageEnglish
Pages (from-to)1198-1205
Number of pages8
JournalJournal of Clinical Periodontology
Volume39
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • anti-Inflammatory agents
  • antimicrobial agents
  • clinical trial
  • delayed-action preparations
  • dental implants
  • peri-implantitis
  • therapy

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