Treatment of experimental mouse bladder tumour by LPS-induced epithelial cell shedding

O. Nativ, O. Medalia, Y. Mor, I. Shajrawi, E. Sabo, M. Aronson

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of the present study was to explore the therapeutic potential of serial administration of shedding-inducing endotoxin in a mouse tumour bladder model. The studies were conducted with two variants derived from the MBT-2 tumour namely, T5 and T50, the latter being far more aggressive than the former. It was found that T5 tumours responded to intravesical lipopolysaccharides (LPS) instillation by a considerable reduction in their pace of growth (P < 0.0001) when treatment was initiated 3 days after tumour implantation, but not when started after 7 days. The T50 variant did not respond to LPS when treated 3 days after implantation, but a considerable reduction in rate of growth occurred when treatment was started after 1-2 days. Shedding induced by intravesically instilled LPS was found to retard considerably the progression rate of experimental bladder tumour.

Original languageEnglish
Pages (from-to)603-605
Number of pages3
JournalBritish Journal of Cancer
Volume74
Issue number4
DOIs
StatePublished - 1996

Keywords

  • Bladder neoplasm
  • Desquamation
  • Lipopolysaccharide
  • Shedding

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