TY - JOUR
T1 - Treatment of early folliculotropic mycosis fungoides with special focus on psoralen plus ultraviolet A
AU - Amitay-Laish, Iris
AU - Prag-Naveh, Hadas
AU - Dalal, Adam
AU - Pavlovsky, Lev
AU - Feinmesser, Meora
AU - Hodak, Emmilia
N1 - Publisher Copyright:
© 2018 Acta Dermato-Venereologica.
PY - 2018/10
Y1 - 2018/10
N2 - Data on the treatment of early folliculotropic mycosis fungoides, a recently defined clinicopathological subgroup of folliculotropic mycosis fungoides with an indolent course, is limited. Treatment outcomes were studied in a retrospective cohort of 47 adults with early folliculotropic mycosis fungoides, with a focus on psoralen plus ultraviolet A (PUVA) monotherapy, including dosimetric data, and the findings were compared with data for PUVA in 18 adults with early-classic mycosis fungoides. PUVA was given to 27 patients with early folliculotropic mycosis fungoides: 70% achieved complete response and 26% partial response. Significantly more treatments were needed to achieve complete response in stage IB compared with stage IA. There was no significant difference in the complete response rate from classic plaque-stage disease, although the early folliculotropic mycosis fungoides group required more treatments to achieve complete response, and a higher cumulative dose of UVA. Thus, PUVA is an effective treatment for early folliculotropic mycosis fungoides. Its complete response rate might be equal to early-classic mycosis fungoides; however, a longer induction phase is needed to achieve complete response.
AB - Data on the treatment of early folliculotropic mycosis fungoides, a recently defined clinicopathological subgroup of folliculotropic mycosis fungoides with an indolent course, is limited. Treatment outcomes were studied in a retrospective cohort of 47 adults with early folliculotropic mycosis fungoides, with a focus on psoralen plus ultraviolet A (PUVA) monotherapy, including dosimetric data, and the findings were compared with data for PUVA in 18 adults with early-classic mycosis fungoides. PUVA was given to 27 patients with early folliculotropic mycosis fungoides: 70% achieved complete response and 26% partial response. Significantly more treatments were needed to achieve complete response in stage IB compared with stage IA. There was no significant difference in the complete response rate from classic plaque-stage disease, although the early folliculotropic mycosis fungoides group required more treatments to achieve complete response, and a higher cumulative dose of UVA. Thus, PUVA is an effective treatment for early folliculotropic mycosis fungoides. Its complete response rate might be equal to early-classic mycosis fungoides; however, a longer induction phase is needed to achieve complete response.
KW - Cutaneous T-cell lymphoma
KW - Folliculotropic
KW - Mycosis fungoides
KW - Phototherapy
KW - Psoralen and ultraviolet a
KW - Puva
UR - http://www.scopus.com/inward/record.url?scp=85056280880&partnerID=8YFLogxK
U2 - 10.2340/00015555-3013
DO - 10.2340/00015555-3013
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C2 - 30085321
AN - SCOPUS:85056280880
SN - 0001-5555
VL - 98
SP - 951
EP - 955
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 10
ER -