TY - JOUR
T1 - Travel- and community-based transmission of multidrug-resistant Shigella sonnei lineage among international Orthodox Jewish communities
AU - Baker, Kate S.
AU - Dallman, Timothy J.
AU - Behar, Adi
AU - Weill, François Xavier
AU - Gouali, Malika
AU - Sobel, Jeremy
AU - Fookes, Maria
AU - Valinsky, Lea
AU - Gal-Mor, Ohad
AU - Connor, Thomas R.
AU - Nissan, Israel
AU - Bertrand, Sophie
AU - Parkhill, Julian
AU - Jenkins, Claire
AU - Cohen, Dani
AU - Thomson, Nicholas R.
N1 - Publisher Copyright:
© 2016, Centers for Disease Control and Prevention (CDC). All Rights Reserved.
PY - 2016/9
Y1 - 2016/9
N2 - Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug– resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.
AB - Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug– resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.
UR - http://www.scopus.com/inward/record.url?scp=84988434171&partnerID=8YFLogxK
U2 - 10.3201/eid2209.151953
DO - 10.3201/eid2209.151953
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AN - SCOPUS:84988434171
VL - 22
SP - 1545
EP - 1553
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 9
ER -