Traumatic ulcerative granuloma with stromal eosinophilia: A reactive lesion of the oral mucosa

Abraham Hirshberg*, Ninette Amariglio, Sharon Akrish, Ran Yahalom, Hanna Rosenbaum, Elimelech Okon, Ilana Kaplan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion of the oral mucosa of an unclear pathogenesis. We analyzed the profile of the inflammatory infiltrate in 12 cases of TUGSE by using immunohistochemical analysis and polymerase chain reaction-based repertoire analysis to detect T- and B-cell receptor gene rearrangements. The inflammatory infiltrate consisted in most cases of B and T lymphocytes, macrophages, abundant eosinophils, and large atypical cells. In 5 cases, CD30+ cells were found. Spectratyping analysis displayed a polyclonal rearrangement of the T-cell receptor γ gene in 6 cases and oligoclonality in 5 cases. Monoclonality was observed in 1 case that also fulfilled histologic criteria for lymphoma. Healing was uneventful in all cases, including the one suspected of being lymphoma, with no recurrences in more than 2 years 'follow-up. TUGSE can be regarded as reactive. Some cases, however, may harbor a dominant clonal T-cell population; in these cases, long-term follow-up is mandatory.

Original languageEnglish
Pages (from-to)522-529
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume126
Issue number4
DOIs
StatePublished - Oct 2006

Keywords

  • Anatomic pathology, head and neck
  • CD30
  • Clinical pathology
  • Eosinophilic ulcer
  • Hematology
  • Lymphoma
  • Traumatic ulcer
  • Traumatic ulcerative granuloma with stromal eosinophilia

Fingerprint

Dive into the research topics of 'Traumatic ulcerative granuloma with stromal eosinophilia: A reactive lesion of the oral mucosa'. Together they form a unique fingerprint.

Cite this