Transverse myelitis associated with chronic hepatitis C

G. Zandman-Goddard, Y. Levy, P. Weiss, Y. Shoenfeld, Pnina Langevitz

Research output: Contribution to journalArticlepeer-review

Abstract

An infectious etiology is one of the postulated mechanisms for autoimmune diseases. An emergence of autoimmune phenomena associated with hepatitis C virus (HCV) infection has been reported Transverse myelitis is an inflammatory disease of the spinal vasculature attributed to viral infections and to autoimmune diseases including systemic lupus erythematosus and the antiphospholipid syndrome. A 34-year-old male was admitted for the rapid onset of numbness of the lower extremities and urinary retention. His past history included hepatitis C infection. The neurological examination and MRI of the thoracic spine confirmed the diagnosis of transverse myelitis. Abnormal laboratory results were hyperglobulinemia, abnormal liver function tests, and positive ANF, antidsDNA antibodies, and p and c-ANCA. The patient was treated with high dose prednisone, then tapered to a low dose, but regained only partial neurological function after 15 months of prednisone therapy. Persistent neurological deficits and elevated ANF and ANCA were present at a follow-up of 30 months. We describe the first reported case of a patient with chronic HCV who developed transverse myelitis.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalClinical and Experimental Rheumatology
Volume21
Issue number1
StatePublished - 2003

Keywords

  • Autoantibodies
  • Autoimmune phenomena
  • Hepatitis C
  • Transverse myelitis

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