Transthoracic needle biopsy in the diagnosis of large-cell neuroendocrine carcinoma of the lung

Sylvia Marmor, Rumelia Koren, Marisa Halpern, Mehrdad Herbert, Lea Rath-Wolfson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


To determine the effect of cytological diagnosis, fine-needle aspiration and brush cytology on lung tumors and core-needle biopsy, we retrospectively reviewed 11 cases of large-cell neuroendocrine carcinoma (LCNEC) found in our archives between the years 1997 and 2004. The preoperative cytological diagnosis of LCNEC is challenging because of the broad histologic similarity to other neuroendocrine tumors of the lung. The original cytologic diagnosis was LCNEC in nine of the cases while the remaining two were misdiagnosed as small-cell lung carcinoma. Smears were composed of clusters of intermediate-size cells with amphophylic cytoplasm, some with large nuclei and prominent nucleoli. In two of the cases there was discordance between the cytological findings and the immunohistochemical results. The cytological findings were correlated with histopathological observations.

Original languageEnglish
Pages (from-to)238-243
Number of pages6
JournalDiagnostic Cytopathology
Issue number4
StatePublished - Oct 2005


  • Fine-needle aspiration
  • Large-cell neuroendocrine carcinoma
  • Lung


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