Transport effects in biochip sensors with redox cycling amplification

Tali Dotan; Michael Nazarenko; Yuval Atiya; Yosi Shacham-Diamand

doi:10.1016/j.electacta.2023.142520

Transport effects in biochip sensors with redox cycling amplification

Tali Dotan, Michael Nazarenko, Yuval Atiya, Yosi Shacham-Diamand^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report a study of transport effects on a microfluidic sensor-chip in which electrochemical sensing is amplified by redox cycling using an interdigitated electrode array (IDA). A full three-dimensional simulation-based model and a simple one-dimensional model for the transition velocity between the two regimes is presented. These models indicate that there exist two dominant regimes: one which is limited by redox cycling diffusion—a unique feature of IDAs— and another which is limited by convection and has dominant flow effects. The transition velocity between the two sensing regimes was found to be v_flow[[Formula presented]]=[Formula presented]+0.04 which is similar to the prediction of v_flow∝[Formula presented], obtained from the one-dimensional model.

Original language	English
Article number	142520
Journal	Electrochimica Acta
Volume	459
DOIs	https://doi.org/10.1016/j.electacta.2023.142520
State	Published - 10 Aug 2023

Keywords

Biosensors
Finite element analysis simulation
Interdigitated electrode array
Mass transport
Redox cycling

Access to Document

10.1016/j.electacta.2023.142520

Cite this

@article{4b73c9387d634399b077e0a69d03dbd7,

title = "Transport effects in biochip sensors with redox cycling amplification",

abstract = "We report a study of transport effects on a microfluidic sensor-chip in which electrochemical sensing is amplified by redox cycling using an interdigitated electrode array (IDA). A full three-dimensional simulation-based model and a simple one-dimensional model for the transition velocity between the two regimes is presented. These models indicate that there exist two dominant regimes: one which is limited by redox cycling diffusion—a unique feature of IDAs— and another which is limited by convection and has dominant flow effects. The transition velocity between the two sensing regimes was found to be vflow[[Formula presented]]=[Formula presented]+0.04 which is similar to the prediction of vflow∝[Formula presented], obtained from the one-dimensional model.",

keywords = "Biosensors, Finite element analysis simulation, Interdigitated electrode array, Mass transport, Redox cycling",

author = "Tali Dotan and Michael Nazarenko and Yuval Atiya and Yosi Shacham-Diamand",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = aug,

day = "10",

doi = "10.1016/j.electacta.2023.142520",

language = "אנגלית",

volume = "459",

journal = "Electrochimica Acta",

issn = "0013-4686",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Transport effects in biochip sensors with redox cycling amplification

AU - Dotan, Tali

AU - Nazarenko, Michael

AU - Atiya, Yuval

AU - Shacham-Diamand, Yosi

PY - 2023/8/10

Y1 - 2023/8/10

N2 - We report a study of transport effects on a microfluidic sensor-chip in which electrochemical sensing is amplified by redox cycling using an interdigitated electrode array (IDA). A full three-dimensional simulation-based model and a simple one-dimensional model for the transition velocity between the two regimes is presented. These models indicate that there exist two dominant regimes: one which is limited by redox cycling diffusion—a unique feature of IDAs— and another which is limited by convection and has dominant flow effects. The transition velocity between the two sensing regimes was found to be vflow[[Formula presented]]=[Formula presented]+0.04 which is similar to the prediction of vflow∝[Formula presented], obtained from the one-dimensional model.

AB - We report a study of transport effects on a microfluidic sensor-chip in which electrochemical sensing is amplified by redox cycling using an interdigitated electrode array (IDA). A full three-dimensional simulation-based model and a simple one-dimensional model for the transition velocity between the two regimes is presented. These models indicate that there exist two dominant regimes: one which is limited by redox cycling diffusion—a unique feature of IDAs— and another which is limited by convection and has dominant flow effects. The transition velocity between the two sensing regimes was found to be vflow[[Formula presented]]=[Formula presented]+0.04 which is similar to the prediction of vflow∝[Formula presented], obtained from the one-dimensional model.

KW - Biosensors

KW - Finite element analysis simulation

KW - Interdigitated electrode array

KW - Mass transport

KW - Redox cycling

UR - http://www.scopus.com/inward/record.url?scp=85159677860&partnerID=8YFLogxK

U2 - 10.1016/j.electacta.2023.142520

DO - 10.1016/j.electacta.2023.142520

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:85159677860

SN - 0013-4686

VL - 459

JO - Electrochimica Acta

JF - Electrochimica Acta

M1 - 142520

ER -

Transport effects in biochip sensors with redox cycling amplification

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this