Transplantation cardiaque néonatale. Premiers résultats.

Translated title of the contribution: Neonatal heart transplantation. First results

L. Houyel, J. Petit, J. Losay, A. Touchot-Kone, J. Bruniaux, G. Blaysat, P. Morville, A. Serraf, F. Lacour-Gayet, C. Planché

Research output: Contribution to journalArticlepeer-review

Abstract

Two 5- and 17-days old neonates with hypoplastic left heart syndrome respectively underwent orthotopic heart transplantation. The donor-recipient weight ratio was +58 percent and +88 percent; ischemic time was 144 and 167 min. The immunosuppressive protocol included thymoglobulin during the induction period and a classical 3-drug therapy, with a rapid tapering off of prednisone over 3 weeks. No infectious complication was observed; each infant experimented one episode of acute rejection, successfully treated with prednisolone. Forty-three months and 10 months later, the 2 children are doing well, with normal renal function and normal growth. No late rejection episode was observed. Heart transplantation in neonates is feasible, the short-term and mid-term results are good. Despite important ethical problems, heart transplantation represents a great hope for neonates with inoperable congenital heart defects.

Translated title of the contributionNeonatal heart transplantation. First results
Original languageFrench
Pages (from-to)2009
Number of pages1
JournalPresse Medicale
Volume21
Issue number41
StatePublished - 2 Dec 1992
Externally publishedYes

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