Transplacental transport and pharmacological manipulations on renotropic activity in post-nephrectomised rats

D/ Modai, Z. Averbukh, E. Rauch, M. Cohn, J. Weissgarten

Research output: Contribution to journalArticlepeer-review

Abstract

Eighty 7-week-old female Charles-River rats were divided into the following groups: SV, sham nephrectomised and remained virgin; NV, underwent right nephrectomy and remained virgin; SP, sham nephrectomised and made pregnant a week later; and NP, underwent right nephrectomy and made pregnant. Each group was further subdivided into four equal groups given water, verapamil, captopril, and indomethacin respectively throughout the experimental period. Following delivery of the pregnancy groups all adult virgin animals and random groups of the offspring were sacrificed, and renal fractional fresh and dry weight as well as protein content were assessed. Results: fractional kidney weights and protein content (mg/kidney) were significantly increased in all nephrectomised adult virgin animals compared to sham-operated counterparts. Similarly, in the offspring of group NP the above parameters were significantly elevated compared to the offspring of SP. However, there was no statistically significant difference concerning these parameters between each of the subgroups within the same groups and its respective control given water. We conclude: (a) in rats, as in mice, post-nephrectomy elevated renotropin crosses the placenta and triggers extra growth of fetal kidneys, and (b) enhanced calcium influx via slow channels, angiotensin II, or increased intrarenal prostaglandin formation do not seem to play an important role in the exaggerated maternal or fetal kidney growth following maternal unilateral nephrectomy.

Original languageEnglish
Pages (from-to)579-583
Number of pages5
JournalNephrology Dialysis Transplantation
Volume5
Issue number8
DOIs
StatePublished - 1990

Keywords

  • Nephrectomy
  • Pharmacotherapy
  • Placenta

Fingerprint

Dive into the research topics of 'Transplacental transport and pharmacological manipulations on renotropic activity in post-nephrectomised rats'. Together they form a unique fingerprint.

Cite this