Transplacental passage of insulin

Renate Kimmerle, Ernst A. Chantelau, Izhar Ben-Shlomo, Jehoshua Dor, Shlomo Mashiach, Shifra Zohar, Ram K. Menon, Mark A. Sperling, Robert M. Cohen

Research output: Contribution to journalLetterpeer-review


To the Editor: Menon et al. (Aug. 2 issue)1 make the interesting observation that animal insulin, mainly in the form of insulin-antibody complexes, can be detected in the cord serum of some infants born to mothers with insulin-dependent diabetes mellitus treated with animal insulin. The authors conclude that the higher rate of macrosomia in infants of such mothers is partly due to the stimulatory effect of the transplacentally transferred insulin.1 We disagree with this conclusion. If the animal insulin transferred from the mother to the fetus contributed to fetal macrosomia, one would expect a lower rate of macrosomia in the.

Original languageEnglish
Pages (from-to)198-199
Number of pages2
JournalNew England Journal of Medicine
Issue number3
StatePublished - 17 Jan 1991
Externally publishedYes


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