TY - JOUR
T1 - Translocation t(3;17)(q23;q21)
T2 - A new translocation in acute lymphoblastic leukaemia
AU - Raanani, Pia
AU - Berkowicz, Miriam
AU - Rosner, Esther
AU - Rosenthal, Ester
AU - Berman, Sara
AU - Rechavi, Gideon
AU - Ben-Bassat, Isaac
PY - 1996
Y1 - 1996
N2 - We report on two adult patients with CD10+ positive acute lymphoblastic leukaemia (ALL) who presented with similar clinical and laboratory features and with a new chromosomal translocation: t(3;17)(q23;q21). This translocation may be involved in the formation of a new chimaeric transcription factor. Both patients shared several poor prognostic factors at presentation and an adverse clinical course. The t(3;17)(q23;q21) translocation may therefore predict a poor outcome in ALL.
AB - We report on two adult patients with CD10+ positive acute lymphoblastic leukaemia (ALL) who presented with similar clinical and laboratory features and with a new chromosomal translocation: t(3;17)(q23;q21). This translocation may be involved in the formation of a new chimaeric transcription factor. Both patients shared several poor prognostic factors at presentation and an adverse clinical course. The t(3;17)(q23;q21) translocation may therefore predict a poor outcome in ALL.
KW - acute lymphoblastic leukaemia
KW - chromosomal translocations
KW - homeobox clusters
KW - homeobox genes
KW - transcription factors
UR - http://www.scopus.com/inward/record.url?scp=0029795004&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.1996.d01-1882.x
DO - 10.1046/j.1365-2141.1996.d01-1882.x
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AN - SCOPUS:0029795004
SN - 0007-1048
VL - 95
SP - 0
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -
